![]() ![]() In this study, a humanized TNFR2 mouse model (TNFR2 HuGEMM) was developed to evaluate the effect of human TNFR2 agonist or antagonist on iTreg differentiation, which may be useful in the development of immunotherapies to treat tumors or autoimmune diseases, respectively. Made for pro Web developers and programmers, MAMP enables easy installation and administration of their development. Moreover, no optimal animal model is currently available for candidate drug evaluation targeting human TNFα-TNFR2. MAMP Pro 5.8 Crack & Serial Key (Torrent) Free Download MAMP Pro Crack is the commercial, professional grade version of the classic local server environment for Operating System X MAMP. However, whether human TNFα-TNFR2 signaling pathway plays similar role on iTreg differentiation remains unknown. Some studies suggest that mouse TNFα inhibits the differentiation of iTregs via TNFR2, providing TNFα-TNFR2 as an attractive target for drug development, for potential control of various diseases including malignant tumors and autoimmune diseases. ![]() Tumor necrosis factor (TNF) α is a pleiotropic cytokine with multiple biological function. Dysregulation of iTreg differentiation is frequently associated with autoimmune diseases or tumors. Background Peripheral induced regulatory T cells (iTreg) play an important role for immune homeostasis.
0 Comments
Leave a Reply. |